CD19-Specific T-cells in Treating Patients With Advanced Lymphoid Malignancies

Condition(s)
Leukemia Lymphoma

Age Group
0-9 years 10-17 years 18-26 years

Phase(s)
1

Drug Pill Drug
Fludarabine Cyclophosphamide

Biological treatment cell Biological
Tisagenlecleucel
Trial Summary

This phase I clinical trial studies the side effects and best dose of CD19-specific T-cells in treating patients with lymphoid malignancies that have spread to other places in the body and usually cannot be cured or controlled with treatment. Sometimes researchers change the deoxyribonucleic acid (DNA) (genetic material in cells) of donated T-cells (white blood cells that support the immune system) using a process called “gene transfer.” Gene transfer involves drawing blood from the patient, and then separating out the T-cells using a machine. Researchers then perform a gene transfer to change the T-cells’ DNA, and then inject the changed T-cells into the body of the patient. Injecting modified T-cells made from the patient may help attack cancer cells in patients with advanced B-cell lymphoma or leukemia.

Ages: 1 Year to 80 Years
Condition: Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia, Blasts 5 Percent or More of Bone Marrow Nucleated Cells, CD19 Positive, Minimal Residual Disease, Non-Hodgkin Lymphoma, Small Lymphocytic Lymphoma,Stage III Chronic Lymphocytic Leukemia, Stage IV Chronic Lymphocytic Leukemia
Status
Active not recruiting
Location(s)
University of Texas MD Anderson Cancer Center, Houston, TX
Contact
Partow Kebriaei, MD
713-792-8750