A Pediatric and Young Adult Trial of Genetically Modified T Cells Directed Against CD19 for Relapsed/Refractory CD19+ Leukemia

Condition(s)
Leukemia

Age Group
0-9 years 10-17 years 18-26 years

Phase(s)
1 2

Biological treatment cell Biological
Patient Derived CD19 specific CAR T cells also expressing an EGFRt
Trial Summary

Patients with relapsed or refractory leukemia often develop resistance to chemotherapy. For this reason, we are attempting to use T cells obtained directly from the patient, which can be genetically modified to express a chimeric antigen receptor (CAR). The CAR enables the T cell to recognize and kill the leukemic cell through the recognition of CD19, a protein expressed of the surface of the leukemic cell in patients with CD19+ leukemia. This is a phase 1/2 study designed to determine the maximum tolerated dose of the CAR+ T cells as well as to determine the efficacy. The phase 1 cohort is restricted to those patients who have already had an allogeneic hematopoietic cell transplant (HCT). The phase 2 is open to all patients regardless of having a history of HCT.

Ages: 1 Year to 26 Years   (Child, Adult)
Condition: CD19+ Acute Leukemia
Status
Recruiting
Location(s)
Children's Hospital Los Angeles, Los Angeles, CA
Children's Hospital Oakland, Oakland, CA
Seattle Children's Hospital, Seattle, WA
Contact
Rebecca Gardner, MD
206-987-2106